Cocaine: a brief history on the discovery, popularisation and early use of medicinal cocaine


  • John H. Thompson Senior Clinical Fellow in Intensive Care Medicine, James Cook University Hospital, UK



Peck TE, Hill SA. Pharmacology for anaesthesia and intensive care. In Chapter 11: Local anaesthetics. 4th ed. Cambridge: Cambridge University Press, 2014; pp. 164–165.

Stripe N, ed. Drug misuse in England and Wales: year ending March 2020. Office for National Statistics: 2020. Available from:
[cited 21 September 2021].

Yorkshire Philosophical Society. Joseph Priestley (1733–1804) – A grand tour. Available from:​/yorkshire-scientists-and-innovators/joseph_priestley/ [cited 30 November 2020].

Lew V, McKay E, Maze M. Past, present, and future of nitrous oxide. Br Med Bull 2018; 125: 103–19. doi: 1093/bmb/ldx050

Duncum BM. Ether anaesthesia 1842–1900. Postgrad Med J 1946; 22: 280–90. doi: 10.1136/pgmj.22.252.280

Desai SP, Desai MS, Pandav CS. The discovery of modern Anaesthesia – contributors of Davy, Clarke, Long, Wells and Morton. Indian J Anaesth 2007; 51: 472–6.

Zuck D, Royal Society of Chemistry. Nitrous oxide: are you having a laugh? Available from: [cited 30 November 2020].

Cartwright F. The early history of ether. Anaesthesia 1960; 15: 67–9. doi: 1111/j.1365-2044.1960.tb13901.x

Bauer I. Travel medicine, coca and cocaine: demystifying and rehabilitating Erythroxylum – a comprehensive review. Trop Dis Trav Med Vaccine 2019; 5: 1–14. doi: 10.1186/s40794-019-0095-7

Calatayud J, González A. History of the development and evolution of local anesthesia since the coca leaf. Anaesthesiology 2003; 98: 1503–8. doi: 10.1097/00000542-200306000-00031

Dronsfield A, Ellis P. Cocaine – a short trip in time. Available from:​2020119.article [cited 30 December 2020].

Gootenberg P. Andean cocaine: the making of a global drug. Chapel Hill, NC: The University of North Carolina Press; 2008.

De Lestrange A. Coca Wine: Angelo Mariani’s miraculous elixir and the birth of modern advertising. Rochester, Vermont: Park Street Press; 2018. Chapter: Angelo Mariani, Father of Coca Wine – The Beginnings of Vin Mariani, Which Would Become the Most Popular Prescribed Medicine in the World. Park Street Press Rochester, Vermont.

Botes M. Vin Mariani – Saint or sinner?: intellectual property. Without Prejudice 2012; 12: 33–4.

Mariani & Company. Coca Erythroxylon (Vin Mariani): its uses in the treatment of disease: with notes and comments by prominent physicians. 4th ed. Paris: Mariani & Co; 1886. Available from: [cited 26 May 2021].

Emery E. Viral marketing: Mariani Wine testimonials in Early French and American newspaper advertising. Nineteenth-Century Contexts 2017; 39: 117–29. doi: doi: 10.1080/08905495.2017.​1284567

Nathan J, Asadourian L, Erlich MA. A brief history of local anaesthesia. IJHNS 2016; 7: 29–32. doi: 10.5005/jp-journals-​10001-1261

Wulf HFW. The centennial of spinal anesthesia. Anaesthesiology 1998; 89: 500–6. doi: doi: 10.1097/00000542-199808000-00028

Bier A. Versuche über Cocainisirung des Rückenmarkes. Deutsche Zeitschrift für Chirurgie 1899; 51: 361–9. doi: 10.1007/BF02792160

Petersen RC, Corfman EL, editors. Cocaine: 1977 – NIDA research monograph #13. In Chapter 1: History of cocaine. Washington, DC: U.S. Government Printing Office, 1977; pp. 17–34.

*John H. Thompson
Intensive Care
James Cook University Hospital,
Middlesbrough, UK.



How to Cite

Thompson, J. H. (2021). Cocaine: a brief history on the discovery, popularisation and early use of medicinal cocaine. Journal of Global Medicine, 1(2), e29.



History of Medicine