Anaesthetic preconditioning and its role in protecting patients at risk of myocardial ischaemia


  • Alastair Duggie Department of Anaesthesia, University Hospital of North Durham, Durham, United Kingdom
  • Jacob McDermott Department of Anaesthesia, University Hospital of North Durham, Durham, United Kingdom



Anaesthetic volatile agents, ischaemic preconditioning, cardiac surgery, anaesthetic preconditioning


Ischaemic preconditioning is a phenomenon where prior minor ischaemic events allows organs to better withstand further episodes of ischaemia. Preconditioning downgrades the effects of ischaemia from necrosis to apoptosis to cell survival. It occurs in a wide variety of tissues, but it is most widely studied in the heart, and it occurs after a range of stimuli including hypoxia and the use of volatile anaesthetic agents. In this article, we look at the basic science, mechanisms, and potential uses of preconditioning.


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How to Cite

Duggie, A., & McDermott, J. (2021). Anaesthetic preconditioning and its role in protecting patients at risk of myocardial ischaemia. Journal of Global Medicine, 1(2), e45.